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Weeks 8-12 : More significant improvements in deeper wrinkles, continued collagen density increase, improved skin thickness (measured via ultrasound in clinical settings), and sustained reduction in age-related skin laxity

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Data was acquired using Thermo Xcalibur 4.0 Software (Thermo Scientific, Waltham, MA USA) MS data processing and analysis were made using Skyline software (V20, MacCoss Lab, University of Washington, Seattle, WA)